Maintenance therapy using a prolonged course of low-toxicity medications is often used to prevent relapse. A selected group of people with documented hypogammaglobulinemia may benefit from replacement immunoglobulin therapy to reduce the risk of infection. Related conditions include solitary plasmacytoma a single tumor of plasma cells, typically treated with irradiation , plasma cell dyscrasia where only the antibodies produce symptoms, e. Kidneys can be damaged by the effects of proteins or light chains. Chemotherapy-induced peripheral neuropathy and thrombocytopenia are major side effects of bortezomib. Archived from the original on 11 January For these people, the standard of care has been chemotherapy with melphalan and prednisone. Myeloma cells produce monoclonal proteins of varying types, most commonly immunoglobulins antibodies and free light chains , resulting in abnormally high levels of these proteins in the blood.