For herpes specifically—which affects about one in every six Americans according to the Centers for Disease Control and Prevention , by the way—it's typically nerve- or inflammation-related, says Anil. Pelvic inflammatory disease—an infection of your uterus, fallopian tubes, or ovaries —is another inflammatory condition that can cause pain in your vagina. Pelvic pain along with back pain, abnormal bleeding, brown discharge, fatigue, nausea and weight loss is a symptom of cervical cancer. Yeast infections So, the most common symptoms of yeast infections are more on the itching and burning side of things, says Gokhan Anil, MD , an ob-gyn in the Mayo Clinic Health System. Docs aren't sure exactly what triggers it, but sex and your period can throw off your vaginal pH. If you feel like your va-jay-jay doesn't lubricate the way it used to, it might be time to check in with your doctor, says Anil. Endometriosis is typically treated with hormone therapy or surgery to remove any tissues that are causing pain.