What does it mean if you have a cough that just won't go away? Chronic Cough: Evaluation and Management. There are some ways in which a lung cancer cough can be different, but the truth is that there is much overlap, and you can't really tell from a cough alone whether someone is likely to have lung cancer. Blood tests may be done to look for any evidence of infection. A Surprising Cause of Chronic Cough. For example, fever, shortness of breath , allergy symptoms, wheezing , or unexplained weight loss? Eosinophilic bronchitis is similar to asthma in some ways based on the type of immune cells present, but these cells are drawn to a different part of the airway. A cough due to GERD is usually worse at night after lying down in bed. Chronic cough: evaluation and management.